Publications

Nature Medicine

Democratizing precision oncology with SCORPIO

Chowell D, Morris LGT. Nature Medicine – Research Briefing. 2025.

Nature Medicine

Prediction of checkpoint inhibitor immunotherapy efficacy for cancer using routine blood tests and clinical data

Yoo SK*, Fitzgerald CW*, Cho BA*, Fitzgerald BG*, et al. Nature Medicine. 2025.

Trends in Cancer

Genetic immune escape in cancer: timing and implications for treatment

Martínez‑Jiménez F, Chowell D. Trends in Cancer. 2025.

Nature Medicine

Neoantigen immunogenicity landscapes and evolution of tumor ecosystems during immunotherapy with nivolumab

Alban TJ, Riaz N, Parthasarathy P, et al. Nature Medicine. 2024.

Nature Cancer

LORIS robustly predicts patient outcomes with immune checkpoint blockade therapy using common clinical, pathologic and genomic features

Chang TG, Cao Y, Sfreddo HJ, Dhruba SR, et al. Nature Medicine. 2024.

Science

An immunogenetic basis for lung cancer risk

Krishna C*, Tervi A*, Saffern N*, Wilson EA*, et al. Science. 2024.

Nature Genetics

Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors

Zapata L, Caravagna G, Williams MJ, et al. Nature Genetics. 2023.

Cancer Cell

NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer

Salome B, Sfakianos JP, Ranti D, et al. Cancer Cell. 2022.

Nature Genetics

Functional landscapes of POLE and POLD1 mutations in checkpoint blockade-dependent antitumor immunity

Ma X, Riaz N, Samstein RM, et al. Nature Genetics. 2022.

Cancer Discovery

A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear-Cell Renal Cell Carcinoma

Rappold PM*, Vuong L*, Leibold J, et al. Cancer Discovery. 2022.

Nature Biotechnology

Improved prediction of immune checkpoint blockade efficacy across multiple cancer types

Chowell D*, Yoo SK*, Valero C*, et al. Nature Biotechnology. 2021.

Cell

Pharmacologic modulation of RNA splicing enhances anti-tumor immunity

Lu SX*, De Neef E*, Thomas JD, et al. Cell. 2021.

Cancer Cell

Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy

Krishna C, DiNatale RG, Kuo F, et al. Cancer Cell. 2021.

Immunity & Ageing

Genetic and environmental determinants of human TCR repertoire diversity

Krishna C*, Chowell D*, Gonen M, Elhanati Y, et al. Immunity & Ageing. 2020.

Nature Medicine

Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy

Chowell D*, Krishna C*, Pierini F*, et al. Nature Medicine. 2019.

Nature Medicine

Immunogenic neoantigens derived from gene fusions stimulate T cell responses

Yang W*, Lee KW*, Srivastava RM*, et al. Nature Medicine. 2019.

Nature Reviews Cancer

The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy

Havel JJ*, Chowell D*, Chan TA. Nature Reviews Cancer. 2019.

Science

Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy

Chowell D, Morris LGT, Grigg CM, et al. Science. 2018.

Cancer Research

Modeling the subclonal evolution of cancer cell populations

Chowell D, Napier J, Gupta R, Anderson KS, et al. Cancer Research. 2018.

Cell

Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab

Riaz N*, Havel JJ*, Makarov V*, et al. Cell. 2017.

Cancer

Diagnostic accuracy of serum antibodies to human papillomavirus type 16 early antigens in the detection of human papillomavirus-related oropharyngeal cancer

Dahlstrom KR*, Anderson KS*, Field MS, et al. Cancer. 2017.

Genome Biology

When (distant) relatives stay too long: implications for cancer medicine

Chowell D, Boddy AM, Mallo D, Tollis M, et al. Genome Biology. 2016.

Clinical Cancer Research

HPV Serum Antibodies as Predictors of Survival and Disease Progression in Patients with HPV-Positive Squamous Cell Carcinoma of the Oropharynx

Dahlstrom KR, Anderson KS, Cheng JN, et al. Clinical Cancer Research. 2015.

Proceedings of the National Academy of Sciences

TCR contact residue hydrophobicity is a hallmark of immunogenic CD8(+) T cell epitopes

Chowell D*, Krishna S*, Becker PD, et al. Proceedings of the National Academy of Sciences. 2015.

The Lancet Infectious Diseases

Modelling the effect of early detection of Ebola

Chowell D, Castillo-Chavez C, Krishna S, Qiu X, et al. The Lancet Infectious Diseases. 2015.