Nature Medicine
Democratizing precision oncology with SCORPIO
Chowell D, Morris LGT. Nature Medicine – Research Briefing. 2025.
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Publications
Nature Medicine
Prediction of checkpoint inhibitor immunotherapy efficacy for cancer using routine blood tests and clinical data
Yoo SK*, Fitzgerald CW*, Cho BA*, Fitzgerald BG*, et al. Nature Medicine. 2025.
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Nature Cancer
LORIS robustly predicts patient outcomes with immune checkpoint blockade therapy using common clinical, pathologic and genomic features
Chang TG, Cao Y, Sfreddo HJ, Dhruba SR, et al. Nature Medicine. 2024.
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Nature Medicine
Neoantigen immunogenicity landscapes and evolution of tumor ecosystems during immunotherapy with nivolumab
Alban TJ, Riaz N, Parthasarathy P, et al. Nature Medicine. 2024.
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Trends in Cancer
Genetic immune escape in cancer: timing and implications for treatment
Martínez‑Jiménez F, Chowell D. Trends in Cancer. 2025.
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Science
An immunogenetic basis for lung cancer risk
Krishna C*, Tervi A*, Saffern N*, Wilson EA*, et al. Science. 2024.
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Nature Genetics
Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors
Zapata L, Caravagna G, Williams MJ, et al. Nature Genetics. 2023.
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Nature Genetics
Functional landscapes of POLE and POLD1 mutations in checkpoint blockade-dependent antitumor immunity
Ma X, Riaz N, Samstein RM, et al. Nature Genetics. 2022.
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Cancer Discovery
A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear-Cell Renal Cell Carcinoma
Rappold PM*, Vuong L*, Leibold J, et al. Cancer Discovery. 2022.
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Cancer Cell
NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer
Salome B, Sfakianos JP, Ranti D, et al. Cancer Cell. 2022.
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Nature Biotechnology
Improved prediction of immune checkpoint blockade efficacy across multiple cancer types
Chowell D*, Yoo SK*, Valero C*, et al. Nature Biotechnology. 2021.
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Cell
Pharmacologic modulation of RNA splicing enhances anti-tumor immunity
Lu SX*, De Neef E*, Thomas JD, et al. Cell. 2021.
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Cancer Cell
Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy
Krishna C, DiNatale RG, Kuo F, et al. Cancer Cell. 2021.
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Immunity & Ageing
Genetic and environmental determinants of human TCR repertoire diversity
Krishna C*, Chowell D*, Gonen M, Elhanati Y, et al. Immunity & Ageing. 2020.
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Nature Medicine
Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy
Chowell D*, Krishna C*, Pierini F*, et al. Nature Medicine. 2019.
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Nature Medicine
Immunogenic neoantigens derived from gene fusions stimulate T cell responses
Yang W*, Lee KW*, Srivastava RM*, et al. Nature Medicine. 2019.
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Nature Reviews Cancer
The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy
Havel JJ*, Chowell D*, Chan TA. Nature Reviews Cancer. 2019.
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Science
Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy
Chowell D, Morris LGT, Grigg CM, et al. Science. 2018.
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Cell
Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab
Riaz N*, Havel JJ*, Makarov V*, et al. Cell. 2017.
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Cancer Research
Modeling the subclonal evolution of cancer cell populations
Chowell D, Napier J, Gupta R, Anderson KS, et al. Cancer Research. 2018.
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Cancer
Diagnostic accuracy of serum antibodies to human papillomavirus type 16 early antigens in the detection of human papillomavirus-related oropharyngeal cancer
Dahlstrom KR*, Anderson KS*, Field MS, et al. Cancer. 2017.
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Genome Biology
When (distant) relatives stay too long: implications for cancer medicine
Chowell D, Boddy AM, Mallo D, Tollis M, et al. Genome Biology. 2016.
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Clinical Cancer Research
HPV Serum Antibodies as Predictors of Survival and Disease Progression in Patients with HPV-Positive Squamous Cell Carcinoma of the Oropharynx
Dahlstrom KR, Anderson KS, Cheng JN, et al. Clinical Cancer Research. 2015.
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The Lancet Infectious Diseases
Modelling the effect of early detection of Ebola
Chowell D, Castillo-Chavez C, Krishna S, Qiu X, et al. The Lancet Infectious Diseases. 2015.
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Proceedings of the National Academy of Sciences
TCR contact residue hydrophobicity is a hallmark of immunogenic CD8(+) T cell epitopes
Chowell D*, Krishna S*, Becker PD, et al. Proceedings of the National Academy of Sciences. 2015.
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